The VBM toolboxes are a collection of extensions to the segmentation algorithm of SPM2, SPM5, and SPM8 (Wellcome Department of Cognitive Neurology) to provide voxel-based morphometry (VBM). The toolboxes are named according to the SPM version. The software was developed by Christian Gaser (University of Jena, Department of Psychiatry) and is available to the scientific community under the terms of the GNU General Public License.

CAT12 is a new software that will replace the previous toolboxes. It contains substantial enhancements over VBM8 and the major difference (except that it’s running under SPM12) consists in the option to estimate and analyze the cortical surface and related parameters such as thickness and gyrification. This major change is now also reflected in the new toolbox name because CAT12 will provide easy-to-use tools that cover diverse morphometric methods such as voxel-based morphometry (VBM), surface-based morphometry (SBM), deformation-based morphometry (DBM), and region- or label-based morphometry (RBM).